Release date: 2016-02-26 Source: Bio 360 ZHANGJIAGANG DINSHENGLIN TRADING CO.,LTD , https://www.dslhouse.com
Recently, scientists in the United States and Japan have found that the spontaneous formation of leaky tumor blood vessels can cause nanoparticles with a diameter of 50 nm or more to aggregate. This new finding is believed to be useful for more effective induction of drug action on tumor cells.
The method of accurately inducing drugs to treat tumor cells is considered to be one of the important means of future tumor treatment. But with current technology, less than 5% of nano drug particles can actually reach the site of action and function because they are either absorbed by the skin, spleen, liver, etc., or they are not able to stay long enough. time.
Scientists have tried their best to increase the probability that drug particles will be absorbed by the tumor and exert a total use, such as improving the permeability of tumor blood vessels. Under this concept, people have invented a solvent that does not penetrate blood vessels, but can diffuse near the tumor cells by a concentration gradient to bring the larger nanoparticles into the blood vessel slowly.
Research groups at the University of Tokyo and the University of Utah have recently discovered that defects in the tumor's blood vessels spontaneously form, and that these defects can increase the amount of nanoparticles entering the blood vessels under the solvent molecules. At the same time, these molecules stay longer in defective blood vessels and are less prone to leakage.
The researchers used a live confocal microscope to observe how the 30 nm and 70 nm diameter fluorescently labeled polymeric nanoparticles moved into the kidney tumor in a 10-minute time interval. The results indicate that large pores or holes in the vessel wall (referred to as "kinetic channels") show a new kinetic characteristic that allows particles larger than 50 nm to stay in the tumor. These transiently formed voids then create a flow of material (called an "outbreak") that rushes into the interstitial space of the tumor. That is, the flow of material "washes" the tumor.
However, these kinetic channels and their properties can not be used for targeted therapy of drugs remains to be verified and studied.
Natural defects in tumor blood vessels provide targeted therapeutic approaches for drugs
Next Article
Fruit trees have many benefits