Simultaneous update of vaccines in 155 countries and regions around the world

In these more than ten days, we will witness a rare scene in the history of mankind - 155 countries and regions around the world will gradually phase out the trivalent polio vaccine (tOPV) that has been in existence for more than half a century before May 1. ), switch to the new bivalent polio vaccine (bOPV). This change will further improve the safety of the vaccine, so that some children with weaker ability to fight infection can also be safely vaccinated.

The existing trivalent polio vaccine is a legend in the history of public health. Since its development in the 1950s, this vaccine, which can prevent Class 1, 2, and 3 polioviruses, has won a battle against the disease. In the 1980s, poliovirus caused more than 350,000 children to fall into disability every year. In the past year, this number has plummeted to double digits. Currently, only Pakistan and Afghanistan still have poliovirus transmission in the world. In these decades, human beings have demonstrated the amazing power to fight disease and eliminate disease.

It is precisely because of the success of the current trivalent polio vaccine that people have not seen the two types of poliovirus since 1999, and it is considered to be “extinct”. At the same time, at the same time, the deactivating virus components in the trivalent vaccine will infect some children with weaker immunity and cause disease in rare cases. Among them, the incidence caused by the two types of virus components accounted for more than 90%. Under the trade-off, The Global Polio Eradication Initiative decided to remove the components of the two types of viruses from the current trivalent vaccine. The decision was also supported by the World Health Organization, the US Centers for Disease Control and Prevention, and the United Nations Children's Fund (UNICEF).

“We are not far from the era of complete polio eradication on a global scale. So we decided to make the largest, fastest, and globally synchronized vaccine replacement in history.” The head of the World Health Organization's Department of Polio Eradication Mr. Michel Zaffran said, “This is a big project, but it also confirms our efforts and achievements in the process of eradicating polio.”

This is indeed a huge project, it must be globally synchronized. This is because if some countries use bivalent vaccines in advance, the risk of infection with Category 2 polio in these countries is likely to increase. As Mr. Jay Wenger, head of the Gates Foundation polio project, said, “Only the global government, the Global Polio Eradication Initiative (GPEI) partners, and the various regulators can work together to complete this huge project.” In order to successfully complete the replacement of this vaccine, thousands of workers around the world will invest in it to ensure that the trivalent vaccine in the vaccine pool on the market and cold chain storage has been properly disposed of.

In order to prevent accidents, children from countries and regions with high polio outbreaks will receive inactivated Class 2 polio vaccines when the global use of bivalent live vaccines begins, further reducing the incidence of Category 2 polio. risk.

We believe that this change from a trivalent vaccine to a bivalent vaccine is another milestone in the history of human public health. It will continue to ensure vaccine safety while significantly improving vaccine safety. At present, except for the two types of viruses that have disappeared for nearly two decades, the three types of viruses have not been reported for three years. This means that we have pushed the polio virus to the border of extinction. Through the continuous efforts of health workers around the world, polio, which once had a major impact on humans, may soon become a term in history textbooks.

Medicines Intermediates

China has become the world's largest producer of Antipyretic And Analgesic drugs. The output of aspirin, paracetamol, analgin and other varieties has exceeded 10,000 tons, and the output of phenacetin, aminopyrine, antipyrine and other varieties has exceeded 1,000. Ton. At present, the output of Antipyretic analgesics in my country is growing rapidly, and it is expected to grow at a rate of about 8% in the future. The production of intermediates for antipyretic and analgesic drugs is large, and there are many manufacturers. With the growth of antipyretic and analgesic drugs, their intermediates have also developed by leaps and bounds.
In 2003, the domestic consumption of paracetamol increased rapidly, and the export also showed a rapid growth momentum. The export volume was 28,163 tons, and the annual export volume increased by about double. In the first half of 2004, although its export growth slowed down, it still increased. From January to May 2004, the export volume of paracetamol was 12,501 tons, slightly higher than the same period last year. Para-aminophenol is an important intermediate in the synthesis of paracetamol, which is growing rapidly. The annual output of p-aminophenol in my country is 32,000 tons. It is estimated that by 2005, the domestic production of paracetamol will reach more than 50,000 tons, and the pharmaceutical industry will consume 45,000 tons of p-aminophenol. The total demand for phenol is about 50,000 tons, the market gap is large, and the development and utilization prospects are broad.

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