Doubt: Can breast cancer be inherited?

With the deepening of epidemiological studies, there is increasing evidence of tumor-related genetics. It has been found that in some people and families there is a family aggregation of so-called cancer families or certain cancers. With the progress of research on the molecular biology of tumor cells, it has been gradually confirmed that there is a tendency of cancer in these family members-loss of heterozygosity of tumor suppressor genes.

This phenomenon makes the body cells of these specific groups easier than other people to carcinogenesis under the multiple effects of carcinogenic factors and cancer promoting factors.

Breast cancer has a certain family genetic predisposition. The clustering of breast cancer in certain families has a risk of up to 50% in the first-degree relatives, and the relative risk in the family is relatively small. Epidemiological survey found that the first-degree relatives of breast cancer patients have a 2-3 times higher risk of developing breast cancer than the general population; in one of their mothers and sisters, women with breast cancer risk the disease. More sexual. This genetic tendency also shows that the incidence of bilateral breast cancer patients is higher than that of unilateral breast cancer patients. Pre-menopausal breast cancer, the patient's first-degree relatives increased the risk of 9 times; post-menopausal breast cancer, the patient's first-degree relatives increased the risk of disease 4 times. From the analysis of the age of onset of breast cancer patients, the younger the age, the greater the risk of relatives having cancer; the more people involved, the greater the risk of relatives.

Although much progress has been made in the study of genetic genes, more studies have shown that tumors are a multi-factor, multi-stage, and multi-mutation multifactorial disease, not just a single intrinsic factor (such as (Genetic defects, etc.) or single external factors (such as carcinogenic environment, etc.) are solely caused by, but are the result of multiple factors alternating and interacting. It should be said that the multiple effects of genetic factors and carcinogenic and carcinogenic factors eventually led to the development of cancer.

In short, the familial aggregation tendency of breast cancer may be related to both genetic and environmental factors, and the use of a single genetic or environmental factor cannot satisfactorily explain the tendency of breast cancer to cluster in the family. However, regular breast examination is necessary and safe for women with breast cancer in first-degree relatives.

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