An international research team consisting of the Salk Institute for Biological Research and the Japanese Institute of Physical Chemistry announced on the 17th that they have developed a new gene editing technology that can be used for the first time on non-dividing cells (present in the eye, brain, pancreas or heart). Effective manipulation is revolutionary for editing the genome of adult living organisms. The team used this technology to partially restore the visual response of blind rodents, which is expected to open up new avenues for basic research and treatment of retinal, cardiac and neurological diseases. In recent years, gene editing technology has developed rapidly and has entered an era in which it is possible to freely select and change base sequences in genes. The existing method utilizes a mechanism of "homologous recombination" at the time of cell division, and inserts a genetic gene of interest anywhere in the genome to repair damaged DNA (deoxyribonucleic acid), which is very effective for dividing cells in the skin or intestine. However, this technique is difficult to apply to cells that do not physically divide, that is, most cells in the living body. The international research team aimed at a DNA repair cell pathway called NHEJ (non-homologous end joining) and combined it with the existing CRISPR-Cas9 system to successfully insert new DNA into non-dividing cells. Site. This genetic modification technique for non-dividing cells was named "HITI", meaning a site-specific gene insertion technique that does not require homologous sequences. Hespax Latex Gloves,White Latex Gloves,Blue Rubber Gloves,Latex Rubber Gloves Jiangsu Hespax Security Co., Ltd , https://www.hespax.com
US Biomedical Research Institute successfully develops non-dividing cell gene editing technology