The effect of obesity on aromatase inhibitors in the treatment of breast cancer

Release date: 2014-08-26

Obesity may affect the efficacy of a common drug, aromatase inhibitors, in the treatment of postmenopausal women with breast cancer. Obesity is now becoming a global trend. It is expected that by 2030, more than half of the world's population will be defined as obesity, obesity and increased risk of multiple cancers and cancers such as colon cancer, endometrial cancer and postmenopausal breast cancer. Poor.

Aromatase inhibitors stop the production of estrogen in postmenopausal women by blocking aromatase. Aromatase converts androgens into small amounts of estrogen, which means that less estrogen can be used to stimulate the growth of hormone receptor-positive breast cancer cells.

Aromatase inhibitors (AIs) prevent the ovaries from producing estrogen, so aromatase inhibitors can only be used in postmenopausal women. Researchers have revealed that the different effects of AI in obese breast cancer patients will help to clarify whether specific AI will produce better results in obese breast cancer patients.

Aromatase inhibitors have been considered the best hormone therapy and are used in early hormone receptor-positive breast cancer patients. Because of the high amount of aromatase in peripheral adipose tissue in obese women, AIs may be less effective for obese women.

Dr. David Porter said: "This study shows that obesity has a negative impact on the efficacy of AI, but the magnitude of the effect (in postmenopausal hormone receptor-positive breast cancer), and whether obesity affects AI is difficult to determine.

So you need to know more before you reach a clinical recommendation. The new study has made it more important for doctors to consider more personalized treatment options, limit the number of unresponsive treatments, and increase the likelihood of successful treatment of all patients.

Source: Bio Valley

Food Additives

Food Additives,Natural Food Additives,Food Additive Saccharin,Popular Food Additives

SHANDONG BAISHENG BIOTECHNOLOGY CO., LTD , https://www.baishengbioproducts.com