New clues to the treatment of basal ganglia-related diseases June 12, 2019 Source: Health News Network Recently, the Institute of Neuroscience of the Chinese Academy of Sciences, the Center for Excellence in Brain Science and Intelligent Technology, and the State Key Laboratory of Neuroscience, Pu Muming, published a paper online in the Proceedings of the National Academy of Sciences, which systematically described the dorsolateral striatum direct pathway and indirect. The electrical activity of the same group of neurons in the path of motion learning changes, and reveals how the electrical activity of the neuron clusters undergoes a time-dependent reconstruction that relies on learning to form a unique and stable sequential distribution pattern, while discovering the two pathways. Neuronal activity has a relatively independent and coordinated role division in athletic behavior. This new discovery provides an important basis for revealing the loop principle of motor learning, and also provides new clues for the research and treatment of dysplasia related to basal ganglia. The dorsolateral striatum brain region plays an important role in the execution of normal motor function, the learning of motor skills, and the formation of habits. This brain region is known to have two classical pathways: direct pathways and indirect pathways. In previous studies, the antagonistic model concluded that direct pathways promoted movement and indirect pathways inhibited movement; the collaborative model concluded that direct pathways promote the generation of desired movements, and indirect pathways inhibit competition that is not related to the purpose. Sexual movement. In this study, researchers focused on three key points: How does exercise learning affect the activity of dorsolateral striatum neurons? Does this effect differ in the direct and indirect pathway neuronal activity of the dorsolateral striatum? If the activity of the two pathway neurons is different, can it reveal the functional differences of pathway specificity? To answer these questions, the researchers used animal experiments to record changes in electrical activity of the same population of neurons during learning. They trained mice to learn a putt motion task under an audible prompt, and used in-vivo two-photon imaging to track the electrical activity of the same group of neurons in the dorsolateral striatum during long-term training. By specifically labeling neurons in the direct and indirect pathways, the researchers observed that, along with the learning process in mice, the neuronal clusters of both pathways gradually produced a unique, stable, sequential distribution of electrical activity patterns. And direct pathway neurons tend to be active during signal sensing and putt operations, while indirect pathway neurons respond more after putt motion. The electrical activity patterns of the same group of neurons change in different motion task scenarios. Further chemical inhibition experiments have shown that specific inhibition of direct pathway neurons disrupts the initiation of putter movement, whereas specific inhibition of indirect pathway neurons causes a significant increase in the number of false putts in the test interval. The suppression of either path reduces the proficiency of the putter action itself. The above studies show that both the direct and indirect pathway neurons are involved in the process of performing the right-handed task in the mouse: in the implementation of the task rules, the former is mainly responsible for the initiation of the target movement, and the latter is mainly responsible for the task purpose. The suppression of irrelevant motion; both of them participate in the regulation of the accuracy of the putter action in the execution of specific actions. The two pathways work together to ensure that the mouse can perform the learning tasks efficiently and accurately. (Reporter Wang Yuyu) epidural catheter,Spinal and Epidural Kit,Spinal and Epidural,epidural needle,epidural kit Anesthesia Medical Co., Ltd. , https://www.trustfulmedical.com
New clues to the treatment of basal ganglia-related diseases
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