Beauty uses skin cells to develop a heart disease model

Release date: 2013-01-31

According to a report by the Physicist Organization Network on January 28 (Beijing time), recently, researchers at the Sanford-Bernham Medical Institute in the United States and Johns Hopkins University collaborated on a patient with hereditary heart disease. The skin cells produce cardiomyocytes and induce a heart disease model in the culture dish, recreating the main features of the disease. The researchers pointed out that this outcome helps people to better study the disease and test new treatments. Related papers were published in the January 27 issue of Nature.
This hereditary heart disease is called arrhythmogenic right ventricular dysplasia/right ventricular cardiomyopathy (ARVD/C). Most patients with this condition have no symptoms before the age of 20, so it is difficult to study their progress and the corresponding treatment. Hui Shengwen, a senior author of the paper and associate professor of the Sanford-Bernham Institute of Medicine, said: "It is very difficult to prove the clinical relevance between the disease model in the culture dish and the disease in adult patients. ARVD/ The symptoms of C usually show up in adolescence, and the stem cells we use are embryos in nature. But our study has a key breakthrough in inducing embryonic cells to possess the metabolism of adult myocardium."
The researchers first collected skin cells from patients with ARVD/C, which contained genetic variants associated with the disease; then added certain molecules to reverse adult skin cells back to a similar embryonic state, ie, induced pluripotent stem cells (iPSCs). State; further induces iPSCs to provide unlimited supply of patient-specific cardiomyocytes. These cardiomyocytes possess most of the embryonic properties, but at the same time carry the patient's initial genetic variation.
The ARVD/C cardiomyocytes in the embryonic stage of the culture dish showed no signs of any disease within one year. They used some mixture to induce the metabolism of cardiomyocytes to be converted from embryonic to adult. Metabolic maturation is the key to inducing embryonic cardiomyocytes to produce adult ARVD/C signals, because human fetal cardiomyocytes use glucose as the main source of energy, and adult cardiomyocytes use fat. They also found the characteristics of the ARVD/C heart in the mutagenized cardiomyocytes, a protein called PPAR that is overactive.
The researchers pointed out that the new model reproduces the disease in culture dishes and provides a new potential drug target for the treatment of the disease. Daniel Garger, associate professor and medical director at the Johns Hopkins University School of Medicine's Center for Genetic Heart Diseases, said: "At present, there is no way to prevent the development of ARVD/C in the world. With this new model, we hope to A life-threatening disease that develops better treatments."

Source: China Science and Technology Network

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