An enhanced HIV vaccine has a new idea through the optimization and transformation of animal experimental vaccines

Release date: 2015-12-03

Through biomineralization technology, scientists have developed an enhanced vaccine that evades pre-existing antibodies in the body, providing a new idea for vaccine optimization and transformation, including HIV vaccines. The HIV vaccine developed based on this technology has passed animal experiments, and the related paper was published online on November 26th in the international authoritative journal “Advanced Materials”.

The research team of the Institute of Advanced Studies of Zhejiang University, Tang Ruikang, the researcher of the State Key Laboratory of Respiratory Diseases of the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, and the team of the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences, Qin Chengfeng, completed the study.

For more than 30 years, the scientific community has conducted initial clinical trials of nearly 200 AIDS vaccines, but the vast majority have failed. Chen Ling believes that "the reasons for failure may include multiple factors, but one of them may be due to the presence of anti-adenotrophic neutralizing antibodies in most humans, which can 'neutralize' the adenoviral vector as an AIDS vaccine, invalidating the vaccine. ."

The scientists have adapted the adenoviral vector carrying the AIDS antigen. Dr. Wang Xiaoyu, the co-first author and the Zhejiang Institute of Advanced Studies, said: "We tried to use the method of biomineralization to put a layer of calcium phosphate film coat on the vaccine to improve the performance of the vaccine." Known as the virus biomimetic mineralization technology. Wang Xiaoyu said: "The 'armed' vaccine is like putting the vaccine into the 'Trojan horse', which effectively escapes the defense line against the neutralizing antibodies of the adenovirus itself and successfully enters the interior of the cell castle." Dr. Sun Caijun from the Guangzhou Institute of Biomedicine and Health said that once the vaccine enters the cell castle, in the acidic environment of lysosomes in the body, the vaccine quickly breaks out from the "trojan" and expresses the target antigen. Initiates a series of immune responses. Without this coat, the adenoviral vector vaccine streaks as if it were contaminated with anti-adenovirus neutralizing antibodies, and most vaccines fail to express antigen and induce immune responses.

Source: China Science and Technology Network - Technology Daily

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