Xi'an Jiaotong University scientists develop micro 3D chips: drug screening for patients with brain tumors

Recently, biomedical engineers from the University of Houston and Xi'an Jiaotong University have developed a miniature 3D chip for drug screening in patients with brain tumors. This device enables personalized anti-cancer therapies at relatively low cost. He is also a co-author of the doctoral tutor of the Center for Bionic Engineering and Biomechanics of Xi'an Jiaotong University and Professor Xu Feng of the “Thousands of Young People” of the Central Organization Department.

Although cell microarrays (arranging living cells on solid surfaces and analyzing large amounts of biological material) are widely found in biomedicine, most current techniques use only 2D cell culture. Because these 2D designs do not reflect the original large environment of most organizations, they have limited value in drug screening and clinical applications. Now, a new study published in the journal Scientific Reports has developed a 3D chip for high-throughput drug screening, making personalized treatment for patients with invasive brain cancer possible.

A team led by Metin Akay of the University of Houston in the United States has developed a drug screening device for the treatment of invasive tumors (called glioblastoma multiforme brain, GBM). Akam said: "GBM is the second most deadly cancer after leukemia, and the average survival after diagnosis is only 15 to 16 months. Our goal is to develop a new, three-dimensional hydrogel-based system. For drug discovery and testing drug efficacy."

Most cell chips used for drug screening are designed to have microfluidic channels - made of a rubber material called poly(dimethylsiloxane) (PDMS) that does not mimic the natural cellular environment. To overcome this limitation, Akay's team used a new gel called poly(ethylene) glycol diacrylate (PEGDA) to create their own chips. PEGDA hydrogels are permeable to water and biomolecules, so they allow the chemicals carried by the chip to “smart release”. The chip releases these chemicals in the 3D environment created by the research team and tests the drug's response.

Due to recent developments in the 3-D tissue model, the research team created more realistic cell-cell/cell-matrix interactions to mimic drug screening in an in vivo environment. Akay pointed out: "The platform we developed will have a huge impact in this area because it enables the use of a very small sample from biopsy and tests which combinations and doses are most effective outside the clinical setting."

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