In this era when everyone wants to "modify" their age, but the young may seem deceptive, the actual age of the body, the risk of aging may be quiet, but it is covered up by the appearance. So, how do you judge the degree of aging? Recently, in a study published in the journal Frontiers of Aging Neuroscience, researchers have identified a natural chemical in the urine. As the age increases, the concentration will become higher, which can truly reflect the aging rate. Biomarker. Cell aging is a measuring ruler The researchers said the chemical could be easily detected in the urine. It can be used as a marker of our "physiological age" or as a marker of aging rate, which is different from the actual age determined by our date of birth. The name of this chemical is 8-oxo-7,8-dihydroguanosine, abbreviated as 8-oxoGsn. It is a by-product of slow, long-term damage to RNA. If the long-term accumulation process of cell and tissue damage can be defined as "aging," then a molecule that can measure ribonucleic acid degradation and maintain healthy cell function can be used as a yardstick to measure aging. The lead author of the study, Dr. Cai from the Beijing Provincial Hospital Key Laboratory of Geriatrics, explained this. Due to the combined effects of genetic and environmental factors, the rate of human aging varies from person to person. Therefore, scientists in the field of geriatrics are always looking for accurate biomarkers that measure the speed of aging. This biomarker can determine the age of a person at the cellular level to determine their risk of age-related diseases such as arthritis, heart disease and Alzheimer's disease. In fact, physical characteristics such as wrinkles and gray hair may obscure the "inner youth" that many older people have. For example, a middle-aged man in his 50s who still maintains a black hair "hair" may be aging faster than a 70-year-old man with white hair, and the risk of aging disease is greater. Men and women have the same level of marking Dr. Cai and colleagues from West China Hospital of Sichuan University are looking for biomarker research based on a leading aging theory, namely the theory of aging free radicals. Free radicals are highly reactive atoms or groups that, if not neutralized by antioxidants, interact with or damage other molecules at the subcellular level. Free radicals produced during normal metabolism can cause oxidative damage to biological molecules in cells, such as DNA and RNA. As we age, we will suffer more and more oxidative damage, and the level of oxidative markers in the body will increase. 8-oxoGsn is a marker that is a well-known by-product of the oxidation of guanine (one of the four base pairs found in DNA and RNA). In previous studies of rats, mice, and monkeys, Dr. Cai and his colleagues found that the levels of 8-oxoGsn in the urine of these animals increased with age. In the latest study, they recruited more than 1,200 men and women between the ages of 2 and 90. Similarly, they found that the increase in 8-oxoGsn in the urine of participants aged 20 years and older was age-related. In other words, the level of biomarkers is higher in people aged 20 years and older. In addition to postmenopausal women, 8-oxoGsn levels are comparable between men and women, and this level is higher in menopausal women. The researchers said that this may be caused by a decrease in estrogen levels during menopause, while estrogen has antioxidant effects. Dr. Cai also said his team hopes to validate their findings in a larger study. (Beijing Morning Post, Chen Xiaodan compiled) Standard Spray Fire Sprinkler,Fire Fighting Sprinkler,Fire Sprinkler System,Dry Sprinkler System NINGBO TOMAN IMP. & EXP. CO., LTD , https://www.tdotmfiresolution.com
Urine can't lie to measure your true age