Release date: 2018-04-26 Researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers. The research team from the Walter and Eliza Hall Institute in Melbourne, Australia, showed switching off a Gene called NF-κB1 caused spontaneous development of stomach cancers, driven by chronic inflammation. Credit: Walter and Eliza Hall Institute This latest study was published in the Cell issue "Immunity" and was led by Professor Andreas Strasser of the Walter and Eliza Hall Institute in Melbourne and Professor Steve Gerondakis of Monash University. They found that inhibition of NF-κB1 protein expression leads to the development of chronic inflammation in the direction of gastric cancer. This means that NF-κB1 protein is the key to prevention and treatment of gastric cancer. Doi.org/10.1016/j.immuni.2018.03.003 Contrary to existing research The article, Dr. Lorraine O'Reilly, said that the findings surprised them because studies have shown that high expression of NF-κB family members is a cause of gastric cancer and other cancers. However, recent research reveals that NF-kB1 is a "heterogeneous" in the family - the expression of NF-kB1 is abnormally low during the induction of gastric cancer. "We found that low levels of NF-kB1 cause uncontrolled severe inflammatory reactions in the stomach. This can lead to the development of invasive gastric cancer in the long term," Dr. O'Reilly said. Immunotherapy for gastric cancer The latest study is the first to construct a preclinical model of gastric cancer, which restores the process of human gastric cancer development, from chronic gastritis to complete invasive gastric cancer. The results show that NF-kB1 deletion leads to JAK-STAT signal disorder, which leads to abnormal expression of inflammation, antigen presentation and immune checkpoint. This reminds us that immunotherapy is expected to become an important treatment for gastric cancer, such as immunological checkpoint inhibitors. All in all, this study not only provides convincing evidence for further study of immunotherapy for gastric cancer, but also provides the first model for preclinical testing of this treatment strategy. Reference materials: Odd one out: Protein goes against the family to prevent cancer Source: Bio-Exploration Measuring Pipettes,Glass Measuring Pipettes,Laboratory Measuring Pipettes,Disposable Serological Pipettes Yancheng Rongtai Labware Co.,Ltd , https://www.rongtailab.com
Unexpected discovery! New ideas for immunotherapy of gastric cancer | Immunity