This high blood pressure drug can extend the life of nematodes by 25%! December 26, 2017 Source: Biological Exploration of: Chen Recently, scientists from the University of Texas Southwestern Medical Center found that a drug approved by the FDA for the treatment of hypertension seems to be able to extend the lifespan of nematodes by "a signalling pathway that mimics heat limitation." The researchers said that the anti-aging effect of this drug may be comparable to the "magic" metformin. Image source: Network 1 life extension of about 25% Nematodes are a useful tool for the scientific community to study aging because they share nearly half of the genes with humans and only survive for about 3 weeks, and during this period, they can show clear signs of age, such as muscle mass loss, fertility and immunity. Decreased function, wrinkled skin, etc. C. elegans (roundworms). Credit: UT Southwestern Medical Center In a paper published in Nature Communications on December 20, the researchers confirmed that a hypertensive drug called hydralazine extended the lifespan of two nematodes by about 25%: one is wild-type nematode The other is a nematode that has been treated to produce a high level of neurotoxic protein tau, which is associated with Alzheimer's disease in humans. 2 key signal path SKN-1 is a transcription factor in nematodes that corresponds to NRF2 in humans. The role of the NRF2 pathway is to protect human cells from oxidative stress. As we age, our body's ability to withstand harmful oxygen free radicals will gradually diminish. One hallmark of aging and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease is oxidative stress. Image source: Nature Communications In this study, scientists used nematodes for in vivo and in vitro studies. The results showed that the lifespan of nematodes treated with azine was extended by about 25% (from 15-18 days to about 20-23 days) compared to the untreated control. At the same time, a series of biochemical experiments It is shown that the prolongation of life induced by azine is dependent on the SKN-1 pathway of nematodes. The related mechanism seems to mimic the heat limit. In addition, in order to test the role of azine in the case of neurodegenerative diseases, the researchers used a high dose of chemical irritant, rotenone. This substance is associated with an increased risk of Parkinson's disease in humans. The results show that pyridazine provides significant neuroprotection. At the same time, oxazine significantly reduced the toxicity of tau in the Alzheimer's disease nematode model. 3 二甲美 metformin, etc. Image source: Mirzaei Lab Dr. Hamid Mirzaei, author of the paper, said: "This is the first report that promethazine treatment can activate the NRF2/SKN-1 signaling pathway. We found that this antihypertensive drug has other potential resistance in extending nematode lifespan. Aging drugs (such as curcumin, metformin) work the same or more effectively." Based on these findings, scientists believe that pyridazine may be a good candidate for clinical trials in the treatment of human age-related diseases, and it is expected to provide general health benefits for the aging population. However, Dr. Mirzaei also stressed that their research is only the first step, and more research is needed to verify this. Reference materials: 1) FDA-approved high blood pressure drug extends life span in roundworms 2) Dieting and extending life expectancy? Scientists reveal the mechanism behind it! Original title: metformin encountered an opponent? This high blood pressure drug can extend the life of nematodes by 25%! Manual Massage Collapsible Foot Spa Massager The Manual Massage Foldable Foot Spa Massager is a portable compact device designed to give your feet a relaxing massage experience. Its foldable design makes it easy to store and transport, making it ideal for the frequent traveler. Manual Massage Collapsible Foot Spa Massager,Foot Bath Massager Machine,Electric Heated Foot Spa,Foot Bath Tub Huaian Mimir Electric Appliance Co., LTD , https://www.footspamachine.com
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This high blood pressure drug can extend the life of nematodes by 25%!