Studies have shown that histone crotonylation is associated with depression December 26, 2018 Source: Ministry of Science and Technology The team of researcher Huang Zhuo, State Key Laboratory of Natural Medicines and Biomimetic Drugs of Peking University, and the research group of Associate Professor Liang Jing of Peking University School of Basic Medicine jointly published a group entitled "CDYL-mediated Group" in the internationally renowned psychiatric journal "Biopsychiatry". A study paper on the regulation of stress-induced depression-like behavior by protein crotonylation (link to the paper https://doi.org/10.1016/j.biopsych.2018.11.025). This study clarified the role of the forebrain histone crotonylation modification and the epigenetic molecule CDYL in the development and progression of depression in the social frustration depression model, and provided a new theory for the development of depression. It provides a potential intervention target for the treatment of depression. According to Huang Zhuo, depression is the most common mental illness in modern society, affecting the normal life of more than 300 million people worldwide. The occurrence of depression is not only regulated by genetics, but also closely related to environmental stress such as stress and traumatic memory. However, the molecular mechanism of environmental stress leading to depression is still unclear. The research team focused on the epigenetic changes in the brain caused by environmental stress, with the epigenetic factor CDYL-regulated histone crotonylation modification (referring to the introduction of crotonyl groups on histone lysine residues) as a cut-in Point, the study of the pathogenesis of depression caused by stress. Using a model of chronic social frustration stress, the researchers found a histone crotonyl hydrolase and transcriptional repressor CDYL, which is significantly elevated in the anterior cortex (PL) of depressed mice, and its mediated histones. The level of crotonylation decreased significantly. When PL overexpresses CDYL, it can increase the susceptibility of mice to depression; conversely, when CDYL is knocked down, the susceptibility of mice to depression can be reduced. High-throughput sequencing of RNA transcriptomes revealed that CDYL can regulate the synaptic plasticity by inhibiting the expression of neuropeptide VGF by transcription, thereby regulating the development of stress-mediated depression. This study first reported the role of histone crotonylation in depression and linked the environmental stress to the pathogenesis of depression. Therefore, this research not only provides a new theory for interpreting the development of depression, but also provides new targets and potential drugs for the treatment of depression, which has important theoretical and practical significance. Collapsible Foot Spa,Foot Spa Bath Massager,Foot Bath Spa Massager,Foot Soak Tub Huaian Mimir Electric Appliance Co., LTD , https://www.footspamachine.com
Studies have shown that histone crotonylation is associated with depression