Shaoyifu Hospital of Zhejiang University: Over-the-Electric Treatment of Alzheimer's Disease

Release date: 2017-12-26

According to statistics, there are about 500,000 patients with Alzheimer's disease in Zhejiang, which is also known as Alzheimer's disease. The reality is that the clinical treatment effect of most patients with Alzheimer's disease is not satisfactory. The drug development is very difficult. When the disease is late, there is often no medicine. With the current instrument, the brain can only focus on the cerebral cortex and cannot stimulate. Deep brain tissue, such as the hippocampus, has limited recovery effects on memory function.

Now, this situation is expected to be changed. Recently, Chen Yu, the director of the Department of Mental Health of the Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, took the lead in the implementation of repetitive transcranial magnetic stimulation (rTMS) treatment, repeated “over-power” of the brain, and introduced a functional magnetic resonance localization method to accurately locate "Stimulate" the hippocampus of the brain and input "magneto" into the hippocampus to produce effective stimulation.

It is understood that the research team of Chen Yu’s team on this treatment – ​​“Research on the comprehensive rehabilitation of cognitive disorders based on transcranial magnetic stimulation and radio wave stimulation aid technology” has been included in the national key research and development plan, which is also the mental health in Zhejiang. The first national key research and development project in the field.

Received ten "over-electromagnetic therapy" memory improved

The 72-year-old grandfather had a memory decline a year ago. He couldn’t remember what he had just done, and he would forget to buy the food when he went out to buy food. I went out to exercise once, but I didn't go home in the middle of the night. When my family went out to look for it, I realized that he was lost.

As the memory declines, the character of the uncles has also changed. He has become timid, does not like to go out, and does not like to interact with his former friends.

In September this year, the family took the uncle to the Shao Yifu hospital for examination. Cognitive, head magnetic resonance (hippocampus) and other related tests showed that he had developed senile dementia. Initially, doctors used cognitive drugs to intervene. However, after taking the medicine, the grandfathers had strong side effects and often felt nausea and nausea. Even if the dosage and medication time were adjusted, they could not be improved.

A month ago, the grandfather learned that the hospital had a new type of non-invasive treatment that could improve cognitive function, so he took part in a two-week treatment with a try-and-see attitude. During the treatment, he did not feel obvious discomfort. When the treatment was over, he felt that his memory had improved.

"Some things can be remembered if you think about it. I didn't remember what I had eaten before I had breakfast. I can still remember most of it when I remember it carefully," said the grandfather's wife. Recently, his mood has improved, he is willing to go out, and he loves to go to the crowd.

It is the repeated transcranial magnetic stimulation (rTMS) treatment that causes the grandfathers to change.

Director Chen Wei introduced that this is the non-invasive neuromodulation technology that has emerged in recent years in the world. The principle is electromagnetic exchange. The magnetic field is generated by a strong current on the electric circle. The magnetic field penetrates the skull and enters the cerebral cortex, so that the corresponding cortex is locally tiny. Current, changing the local electrical activity of the computer cortex, for therapeutic purposes.

In the past, rTMS treatment mainly focused on psychiatric diseases such as depression, sleep disorders, and anxiety disorders. The application of rTMS treatment through functional connection has not been publicly reported in patients with Alzheimer's disease. The uncle is the first case.

Accurate positioning to the "target" repeatedly stimulates the hippocampus

It is understood that foreign preliminary research has found that rTMS has a good application prospect in the treatment of senile dementia and prevention. However, there is a practical problem to be solved: "over-electromagnetic therapy" can only focus on the cerebral cortex. The memory center of the brain is deep in the brain, the magnetic field cannot penetrate, and the effectiveness is significantly reduced.

In 2014, a paper published in the journal Science by Joel Voss of the Northwestern University School of Medicine pointed out that for a group of healthy subjects in the hippocampus, through functional magnetic resonance, it was found that the stimulating function links the located lateral parietal lobe. The regulation of hippocampus function.

For Chen Yu, a long-time clinical and scientific researcher, this research has become an important source of “inspiration”, a new and viable treatment that was born – the introduction of functional magnetic resonance imaging while performing rTMS treatment.

Director Chen Wei said that functional magnetic resonance is equivalent to a positioning navigator, which helps doctors find the best position for effective stimulation of the hippocampus, that is, the stimulation function connection point located at the top of the skull. The point and hippocampus are established by rTMS. Contact, effectively input magnetic power into the deep brain, and produce repeated stimulation to the hippocampus.

"The formation of each person's memory has a corresponding network in the brain. If the network is interrupted or damaged, things can't be remembered. The rTMS treatment continues to stimulate the hippocampus. The purpose is to use magnetic electricity to repair the network and strengthen the network signal transmission. ."

At present, Shao Yifu Hospital is trying to apply rTMS to patients with Alzheimer's disease or mild cognitive impairment with memory impairment. Each treatment lasts for about 30 minutes and will be treated free of charge for the elderly. The hospital is also cooperating with Huzhou Third People's Hospital and Ganzhou Third Hospital. It plans to treat 240 patients with mild senile dementia and 240 patients with mild cognitive impairment. Evaluate and observe specific effects.

Source: Qianjiang Evening News

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