New technology of freezing and preservation of transgenic pig embryos

Biology Report: A research group led by a professor of regenerative biotechnology at the University of Missouri-Columbia recently announced their new results in freezing and preserving transgenic pig embryos. In the process of thawing and transplanting these porcine embryos carrying modified genetic material into surrogate sows, some embryos have developed into live piglets with new genetic characteristics. The results of this study were published on the May 3 Biology of Reproduction website. The researchers pointed out that their new technology may enable genetically engineered pigs to be transported between countries in the world in the form of embryos.
Since many embryos are necessary for the surrogacy of pregnant surrogates, this new method will enable people to collect appropriate transformation embryos and store them when they need to be transplanted to surrogate sows.
Porcine embryos are very cold-sensitive due to the high level of lipids in the embryonic cells, and are therefore difficult to freeze and preserve. Moreover, the freezing and preservation of porcine embryos produced ex vivo is considered to be more difficult. Prather's team overcame this technical hurdle by removing lipids from unfertilized eggs prior to fusing them with muscle cells from male pigs containing modified genetic material. The embryos produced by this method are frozen at the blastocyst stage.
After thawing, the embryos were transplanted to surrogate sows. Experiments have shown that embryos placed in the fallopian tubes of two surrogate sows make the sows pregnant and allow the sows to produce calves successfully.
The results of the analysis showed that these piglets carry genetically altered material and that the new gene changes the fatty acid content in piglets. Next, researchers will also improve this technology. The research team hopes that freezing and preservation of porcine embryos will facilitate the production of pigs carrying economically valuable genetic traits, as well as biomedical research. (Biology reporter Yang Yao)
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Posted on November 17, 2024