Nat Methods: Develop a new technology that accelerates the analysis of the human genome

Nat Methods: Develop a new technology that accelerates the analysis of the human genome

August 10, 2016 Source: Bio Valley

In a study published in the international journal Nature Methods , researchers from Australia developed a new "mold" that reflects the synthetic mirror DNA sequence of the human genome, which is used to map and analyze genomes. Intuitive new technologies of complexity may be used free of charge by academic researchers. The human genome is a very complex sequence of more than 6 billion bases. Although we can now sequence a person's genome cheaply and quickly, the subsequent analysis of the human genome is a very difficult problem.

To improve the quality of human genome analysis, the researchers developed a new technology called Sequins based on synthetic human genome sequences. Researcher Dr. Tim Mercer pointed out that human genome sequencing can change biomedical research and people's health care. As genome sequencing is increasingly used to diagnose disease, it is clear for researchers to understand the accuracy and application of genomic data. It is especially important. In the article, the researcher Mercer and his colleagues added small stretches of synthetic DNA to human DNA samples during the sequencing process. These special synthetic DNAs can then serve as internal standards to help researchers analyze genome sequencing. A large number of data files produced.

Researchers believe that Sequins technology is developed based on an intuitive and relatively simple concept, the concept of mirrored DNA; essentially, sequins are mirror images of natural DNA sequences, and like humans, the genome always has a handedness (' Handedness'), just like our right and left hands, sequins are often different from natural genomic sequences, so sequins behaves like natural genomic sequences, but they are easily distinguishable.

Researcher Mercer pointed out that Sequins technology is the first new technology to apply diagnostic statistics to each individual's genome sequencing experiments, and we predict that this technology can help improve the reliability and sensitivity of the diagnosis of hereditary diseases. Researchers using Sequins technology can now significantly improve the diagnosis of cancer. Combining Sequins technology with clinical trials in cancer diagnosis may increase the reliability of a single diagnostic test, thereby reducing the number of incorrect diagnoses and giving clinicians greater confidence to make patients more accurate diagnoses.

Researcher Professor John Mattick said that Sequins technology can introduce DNA sequencing into clinical standards, and it is also a good platform for genomic research and related research in the field of medicine; Sequins has many potential applications, from bacteria to humans. The genomes of all organisms are rotational, so Sequins can be designed specifically for any organism or used in any next-generation sequencing application.

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