Mechanism of "pre-superbug" infection-induced host cell death January 24, 2018 Source: Science and Technology Daily According to the Kunming Institute of Zoology, Chinese Academy of Sciences, the Institute of Pathogen Infection and Host Immunity Mechanism has made new progress in the study of drug-resistant Acinetobacter baumannii infection-induced host cell death. The research results have been published in the authoritative journal Cell Death and Variation". Acinetobacter baumannii is a Gram-negative bacterium that is widely present in the environment. At present, drug-resistant Acinetobacter baumannii has become a major epidemic pathogen in hospitals. It is highly infectious and pathogenic to people with low immunity. It can cause pneumonia, urinary tract infections, blood-borne infections, and is also a cause of burn infection. The main pathogen. This bacterium has broad-spectrum resistance to a wide range of antibiotics including carbapenems and colistins worldwide, ranking first in level 1 - serious resistance, and full resistance. Acinetobacter baumannii will likely evolve into a "superbug" and its targeted treatment will become increasingly difficult. The research team studied the mechanism of the type I interferon signaling pathway in the regulation of host cell death induced by Acinetobacter baumannii infection. Infection with Acinetobacter baumannii can cause apoptosis and inflammatory death in the host until cell death and cell necrosis. Acinetobacter baumannii infection induces the production of type I interferon through a dependent signaling pathway that mediates histone modification, thereby regulating the expression of key genes for cell death, promoting mediated cell death, necrosis, and Activation of inflammatory bodies. The project was funded by the National Key Research and Development Program, the National Natural Science Foundation of China, the Chinese Academy of Sciences, and the Yunnan Provincial Key Laboratory of Bioactive Peptides. (Zhao Hanbin) Striped Bonito,Sarda orientalis,Fresh Striped Bonito,Fresh Sarda orientalis Zhoushan Boda Aquatic Products Co.,Ltd , https://www.baida-aquatic.com
Mechanism of "pre-superbug" infection-induced host cell death