Beta-thalassemia is a common genetic disease of high incidence in Guangdong. At present, the only cure for thalassemia in the clinic is hematopoietic stem cell (HSCs) transplantation. However, the chances of successfully finding a matching spinal donor are very limited. The thalassemia patients are often not cured and can only be maintained by continuous blood transfusion. life. Can not be transplanted, can you do autologous transplantation? Today, this idea has been realized. Expected to achieve beta-thalass autologous transplantation On the 12th, the reporter learned from the Third Affiliated Hospital of Guangzhou Medical University that the team led by Professor Sun Yifang, the key laboratory of major diseases of Guangdong Province and the key laboratory of the Ministry of Reproductive and Genetic Sciences of Guangdong Province, was edited by CRISPR/Cas9 gene. Technology, successfully correcting the β-globin gene (HBB) mutation in β-thalassian iPSCs (induced pluripotent stem cells), causing it to differentiate into normal hematopoietic stem cells, providing a new type of patient without bone marrow transplant matching donors Autologous transplantation treatment options. The reporter learned that the Sun Yifang team is currently doing this experiment in mice. More than 30 mouse transplant experiments have been successful, and the next step will be to consider experiments on large animals. The cause of thalassaemia stems from genetic mutations Among thalassemia, beta-thalassemia is a common type in Southeast Asian populations. In China, the provinces south of the Yangtze River are high-incidence areas of thalassemia, and the incidence rate in the Guangdong-Guangdong region is particularly high. Beta-thalassemia results from mutations in the HBB gene. Mutations in the HBB gene cause defects in beta hemoglobin synthesis, which ultimately leads to erythropoiesis and anemia. When there is a disorder of erythropoiesis and red blood cells are lost in the body, patients with thalassemia will develop clinical symptoms such as developmental disorders and organ dysfunction. If they are not treated in time, they will lead to death. Many symptoms of thalassemia will gradually develop after half a year of birth. It appears that if you do not intervene, your child often does not live one year old. This catagory includes varities of food additives, including acidity regulators, anticaking agents, defoamers, antioxidants, bleaching agents, leavening agents, coloring agents, color retention agents, enzyme preparations, flavor enhancers, nutritional fortifiers, preservatives, sweeteners, thickening agents Agents, spices, etc. Food Additive,Cooling Agent,Food Cooling Agent,Cooling Agent Powder Hunan Insen Biotech Co., Ltd , https://www.insenhealth.com
Chinese scientists using CRISPR to successfully repair β-thalassemia-deficient genes are expected to achieve autologous transplantation
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