Release date: 2015-10-09 Recently, researchers from the Swiss Federal Institute of Technology in Zurich, East China Normal University, etc., in a study published in the internationally renowned academic journal "Nucleic Acids Research", through the chemical parabens (common skin care) Product ingredients) to turn the transgene on and off. So, can this be used as a non-invasive method for delivering dose-specific transgenic agents? Ye Haifeng, a doctoral tutor at the School of Life Sciences at East China Normal University, participated in the study. Extended reading: Scientists have developed new ways to control gene expression. Transgenic - the transfer of DNA extracted from one organism to another has enormous potential for the treatment of human patients. These DNA fragments can be induced to express important proteins that are deficient in patients due to metabolic diseases. Now, a group of researchers from China, Switzerland and France have found a relatively simple way to switch the switch of transgene expression, which is a big step forward in the development of targeted therapy. What is needed for this method is - shower. Martin Fussenegger, co-author of this article, the Federal Institute of Technology in Zurich and the bioengineer at the University of Basel, points out: "In the future, cell-based therapies require very precise control of the expression of the transgene to adapt to the needs and dynamics of the patient's disease." At this point, Fussenegger and his research team developed a "designer" cell that can be implanted into the body and turned on or off with a remote trigger. Fussenegger said: "This is not because you swallow a drug because it will be cleared first by the liver. This method is better than injection, and the injection is invasive." According to Fussenegger, transdermal administration is a reliable dose. The only non-invasive method of protein therapy. Parabens are plant antibacterial agents that are often used as preservatives in cosmetics and are an ideal triggering compound because they migrate rapidly through the skin and into the bloodstream. Another advantage is that they have been approved by the FDA for ready-to-use daily chemicals such as shower gels, hand creams and toners. Benzoate can destroy a metabolic pathway in the pathogen Pseudomonas syringae, which can cause bacterial spots on tomato plants. Using this sensitive interaction of benzoates, Fussenegger and his colleagues designed a set of mammalian gene switches that allow paraben-sensitive transgenes to be expressed in a variety of human cell lines. Fussenegger said: "The advantage is that you can add more or less parabens to your body wash to achieve a critical dose in your blood that is related to the specific expression of the therapeutic protein." The team found that a benzoate-activated transgenic system can cause expression of the reporter gene SEAP in mammalian HEK-293 cells. Fussenegger said: "In the future, we don't take prescription drugs several times a day. You can adjust your protein treatment by taking a few showers a day." He estimates that clinical trials will be conducted within two to five years. Note: Ye Haifeng, researcher, doctoral tutor. He graduated from Ningbo University with a bachelor's degree in biotechnology in 2004. He graduated from East China Normal University with a master's degree in 2007. He received his Ph.D. in the Department of Biological Systems Engineering from the Federal University of Technology (ETHZ) in Zurich in July 2012. He continued to serve as a postdoctoral researcher in the original research group. jobs. In March 2014, he returned to China to be employed as a young scholar of Zijiang of East China Normal University, a young researcher in biochemistry and molecular biology at the Institute of Life Medicine, and a doctoral tutor. He is mainly engaged in the research of mammalian cell synthesis biology and disease treatment. Related research results were published in "Science", "PNAS", "Curr Opin Chem Biol" and other magazines. Source: Biopass Natural field focus on the production and sales of raw materials for liver protection health care products.Puerarin has protective effects on liver tissue.Dihydromyricetin's main effects are that of gaba/alcohol receptor inhibitor. (Hepatprotective meaning liver/blood protector. Gaba receptor cells uptake alcohol during consumption and the resulting loss of function from loss of GABA uptake produces the effects of intoxication.) Milk Thistle Extract can protects the liver by promoting the growth of new liver cells. Liver'S Protecting Health Material,Liver'S Protecting Supplement,Health Care Liver'S Protecting,Liver Protection Xi'an Natural Field Bio-Technique Co., Ltd. , https://www.naturalnf.com
Can you control gene expression by taking a bath?
Prev Article
What kind of food