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1. Grapefruit should not be taken with lipid-lowering drugs: If you eat grapefruit during the lipid-lowering drugs such as atorvastatin, lovastatin, simvastatin, etc., the possibility of muscle pain and rhabdomyolysis will increase. Acute renal failure can also occur. Clinical observation found that patients with hyperlipidemia use a cup of grapefruit juice to take a lovastatin (also known as the United States lipid-lowering), the result is equivalent to a 12-l5 tablet of lovastatin in a cup of water to reduce blood fat, the patient will Muscle pain and even kidney disease.
2, grapefruit should not be taken with antihypertensive drugs : because grapefruit itself also has antihypertensive effect, plus it can also increase the blood concentration of antihypertensive drugs, taking nifedipine, nimodipine, verapamil and other antihypertensive drugs Eating grapefruit or drinking grapefruit juice during the period is like overdosing, causing sudden drop in blood pressure, causing dizziness, palpitation, fatigue, and angina, myocardial infarction or stroke.
3, grapefruit should not be taken with sedative sleeping pills: grapefruit will increase the possibility of dizziness and drowsiness caused by drugs such as diazepam (diazepam) and midazolam. Especially for high-altitude workers and drivers during medication.
4, grapefruit should not be taken with the contraceptive: grapefruit will hinder the absorption of contraceptives by women. Women who take birth control pills may lose their contraception if they eat grapefruit after sex. A study in the United States shows that grapefruit has the most prominent effect on contraceptives. Experts said that "if a woman taking a birth control pill eats 1 or 2 grapefruits after sex, or directly uses a large cup of grapefruit juice to take the pill, then she may become a mother because the grapefruit is hindered. The absorption of contraceptives by women."
5, grapefruit should not be taken with anti-allergic drugs: grapefruit may induce adverse reactions such as terfenadine and other anti-allergic drugs, causing dizziness, palpitations, arrhythmia and other symptoms.
6, grapefruit should not be taken with immunosuppressants: grapefruit can increase the blood concentration of cyclosporine and other immunosuppressants, increase liver and kidney toxicity. If these drugs are eaten with fruits such as grapefruit for a long time, there is a risk of inducing tumors.
Among the drugs that have adverse effects on grapefruit are: cyclosporine, caffeine, calcium antagonist, cisapride and the like. Drinking a cup of grapefruit juice will last 24 hours with the drug. Therefore, patients who are taking medicine, especially the elderly, should not eat grapefruit or grapefruit juice. In addition, grapefruit contains a lot of potassium, and patients with kidney disease need to consult a doctor before eating grapefruit. People who have spleen diarrhea and eat citron will have diarrhea, so people with debilitating body should not eat more.
Grapefruit contains an unknown active substance, which inhibits an enzyme in the human intestine, causing the normal metabolism of the drug to be disturbed, and the blood concentration of the drug is significantly increased. Affects liver detoxification, damages liver function, may cause other adverse reactions, and even cause poisoning. The study found that after taking grapefruit or drinking grapefruit juice, the blood concentration may be several times to several hundred times higher than that after drinking water. If you drink the grapefruit juice and take it after a while, you will find the concentration of grapefruit juice on the blood. The elevation effect can persist for 24 hours; only after 3 to 7 days, the effect of grapefruit juice gradually disappears. Therefore, for safety reasons, you should avoid eating grapefruit or grapefruit juice 3 days before taking the medicine and 6 hours after taking the medicine. It is best not to eat fruits such as citrus. Otherwise, you should consult your doctor to adjust the dosage of the drug, or follow the doctor's advice to switch to other drugs.
Can't eat grapefruit when eating these six medicines
[China Pharmaceutical Network Health Health] Grapefruit is delicious and is one of the most popular fruits. Grapefruit is fragrant, sweet and sour, cool, nutritious, and has high medicinal value. It is also recognized as the most therapeutic fruit in the medical world. And winter is a good time to eat grapefruit. Modern medical research has found that pomelo meat contains very rich vitamin C and insulin-like ingredients, so it has the effects of lowering blood sugar, lowering blood fat, losing weight, and improving skin. However, experts pointed out that when eating certain drugs, do not eat grapefruit. The active ingredient in grapefruit can inhibit the activity of liver drug enzymes, and many drugs need to be excreted through the metabolism of liver drug enzymes. If you take this kind of medicine while eating grapefruit, the drug can not be metabolized and accumulate in the body, which may cause too much effect, affect treatment, and even have adverse reactions.
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