The National Academy of Sciences has discovered a new approach to ultrasound gene therapy for heart disease and cancer

Recently, an article published in the Proceedings of the National Academy of Sciences pointed out that the combination of ultrasound energy and ultrasound microbubbles to perforate cells may become a new tool to combat cardiovascular disease and cancer. Researchers at the University of Pittsburgh called the gene therapy a sonic effect therapy. Xiaobian compiled and compiled related information.

To be simple, we refer to the biophysical mechanism of ultrasound-triggered cell membrane rupture as the sonic effect. The research on the effect of sound control is mainly related to the physical stimulation of ultrasonic microbubble vibration and the resulting cell membrane permeability. It has been shown by research that there is a shear stress threshold caused by microbubble oscillation, about 1 kPa, and when the pressure exceeds this value, endothelial cell membrane permeability increases. The shear stress threshold shows an inverse square root relationship with the number of oscillation periods and the ultrasonic frequency from 0.5 Hz to 2 Hz. In addition, measurements by real-time three-dimensional confocal microscopy demonstrated that a somatoporation process directly causes the cells to form membrane pores immediately by encapsulation of the apical and basal cell membrane layers along their outer side (sealing time < 2 minutes). The sonoporation effect also has great potential for cell fusion, which allows two adjacent cells to fuse within 30-60 minutes.

Dr. Brandon Helfield, MD, researcher at the Ultrasound Molecular Imaging and Therapy Center at UPMC, said: "The researchers use ultrasound energy and small bubbles to selectively open a small hole in the cell for drug delivery. Using focused ultrasound beams, we can stay healthy. At the same time as the organization, the drug is accurately delivered to the lesion. We focus on the role of biophysics in this area, and improve the diagnosis by improving the technology."

In current methods of gene therapy, researchers often use viruses to bring genes into cells for cultivation. This method produces strong side effects, such as the immune system response. To solve this problem, researchers have developed intravascular microbubbles that carry genes that can specifically release their own genes by focusing ultrasound energy.

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