The Chinese team revealed that metformin delays the new mechanism of human cell aging April 26, 2018 Source: Institute of Biophysics Metformin is currently the first line of treatment for type 2 diabetes. In recent years, studies have reported that metformin has the ability to delay the aging of lower animals. However, it is unclear whether metformin also has a protective effect on human cellular aging. A collaborative study between Wang Zhizhen and Liu Guanghui's research team found that long-term, low-dose (similar to the drug concentration in venous blood of diabetic patients taking metformin) can delay the replication of human diploid fibroblasts and mesenchymal stem cells. Sexual aging. It was also found that metformin enhanced the transcriptional activity of the antioxidant transcription factor Nrf2 and up-regulated the expression of endoplasmic reticulum GPx7. Previous studies by Wang Zhizhen's group have shown that GPx7 plays an important role in the oxidative folding and redox homeostasis of endoplasmic reticulum proteins (Antioxid Redox Signal, 2014). The study found that the expression level of GPx7 was significantly reduced with human cell senescence, and knocking down GPx7 accelerated human cell senescence and promoted stem cell depletion in vivo. In the Nrf2 genetically enhanced "longevity" stem cells established by Liu Guanghui's research group (Cell Research, 2017), the expression level of GPx7 was significantly increased. Interestingly, the Nrf2-GPx7 signaling pathway also plays a key role in the prolongation of metformin-induced nematode lifespan. Metformin can up-regulate the expression of nematode GPX-6 (a homolog of human GPx7) by activating the homologous protein of Nrf2 in nematodes; knocking down GPX-6 significantly inhibits the prolongation of metformin to nematodes. Metformin delays cell senescence through the Nrf2-GPx7 signaling pathway This study provides important experimental evidence and mechanism for the delay of human cell senescence in metformin, and establishes a scientific link between the endoplasmic reticulum redox state and human cell aging. At the same time, targeting the Nrf2-GPx7 pathway also provides new ideas for the prevention and treatment of aging-related diseases. Doi.org/10.1111/acel.12765 Associate Professor Wang Lei (Wang Zhizhen) and researcher Liu Guanghui, co-reporter of the paper, Wang Zhizhen, Ph.D., Fang Jingqi, Wu Xun and Liu Guanghui, Ph.D. student Yang Jiping, are the co-first authors of the paper. The research was strongly supported by Zhang Hong, a researcher at the Institute of Biophysics, and was funded by the National Key Research and Development Program, the National Natural Science Foundation, the Strategic Leadership Program of the Chinese Academy of Sciences, and the Chinese Academy of Sciences Youth Innovation Promotion Association. Wheat Seed,Winter Wheat Seed,Wheat Varieties,Organic Wheat Seeds XIKE AGRICULTURAL GROUP CO . .LTD. , https://www.laoseed.com
The Chinese team revealed that metformin delays the new mechanism of human cell aging