Take a closer look at the top three medical technologies in the world's top 10 breakthrough technology list in 2017

The MIT Technology Review has released four major medical- related technologies in the list of the world's top 10 breakthrough technologies in 2017.

Recently, "MIT Technology Review" released the list of the world's top 10 breakthrough technologies in 2017. The MIT Technology Review has the world's top ten breakthrough technologies with great global influence and authority. 16 years. Some of the annual rankings have already been applied in reality, and some still take time, but their importance is undoubtedly ruthless, destined to have a major impact on our economic and political life in the future, and even completely change the whole The cultural face of society.

Extended reading: MIT released 2017 global top ten breakthrough technologies (click to view)

Based on the content of the Internet, the author has compiled three breakthrough technologies related to medical care, and expects that these new technologies will bring greater changes to the future medical care.

Technological breakthroughs: The United States is about to approve the first gene therapy technology, and more gene therapy is under development and approval.

Important: Many diseases are caused by a single genetic mutation, and new gene therapy can completely cure these diseases.

Maturity: now

Researchers have been pursuing the dream of gene therapy for decades. The prospects for gene therapy are very good: use a modified virus to deliver a healthy copy of the relevant gene to a patient carrying a defective gene. However, so far, the disappointment caused by gene therapy is far greater than hope. In 1999, an 18-year-old liver disease patient, Jesse Gelsinger, died in a gene therapy experiment, and the development of the entire gene therapy field has since stagnated.

Part of the reason for the failure of early gene therapy stems from its delivery mechanism, because new genetic material (engineering genes) and carrier viruses that carry them to cells are erroneously delivered to other locations in the genome, which activates certain patients. An oncogene in the body, or an overreaction to the patient's immune system, leading to multiple organ failure and brain death.

But now, some key problems have been solved, and gene therapy will also usher in the dawn. Researchers have used more efficient viruses to transport new functional genes into cells.

Now, gene therapy for two genetic diseases: Strimvelis, which treats a SCID disease, and Glybera, which treats a disorder that causes fat to accumulate in the blood, has been approved by relevant authorities in Europe.

In the United States, Spark Therapeutics is expected to be the first gene therapy startup to enter the market, which has developed gene therapy for progressive blindness. There are many other gene therapies under study that are eyeing the treatment of hemophilia and a hereditary skin disability called epidermolytic vesicular disease.

Although gene therapy has been developed for several relatively rare diseases, it is more difficult to develop corresponding gene therapies for common diseases with complex genetic causes.

For diseases like SCID and hemophilia, scientists know exactly the exact genetic mutations that cause disease. However, diseases such as Alzheimer's disease, diabetes, and heart failure involve not only multiple genes, but also corresponding gene mutations in different patients with the same disease.

Currently, researchers in related fields include: Spark Therapeutics, BioMarin, GenSight Biologics, BlueBird Bio, and UniQure.

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