Release date: 2017-12-18 On December 14th, the latest issue of "Cell" journal entitled "Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA" revealed a long non-coding RNA, THOR, although not encoding proteins, But it has a "direct impact" on cancer cells. Scientists have recently discovered that silencing THOR can prevent tumor expansion. "garbage" DNA The human genome contains more than 3 billion DNA base pairs, consisting of about 2 to 25,000 genes, occupying less than 2% of the genome sequence, and the remaining 99% of the DNA is located in the non-coding region, which was once considered " The garbage sequence (without actual effect) is called the "dark matter" in the genome (because it is poorly understood). In recent years, with the development of gene sequencing technology, more and more "junk" DNA has been confirmed not to be "garbage." Scientists have found that these non-coding genes, although not expressing proteins, produce non-coding RNAs that are rich in information and have important biological functions, including a series of long non-coding RNAs consisting of more than 200 nucleotides ( lncRNA). Find highly conservative "dark matter" In the latest study, scientists discovered a long non-coding RNA and confirmed it to be the same in zebrafish, mice, and humans. Considering the rare discovery of "conserved" RNA between different species, the research team speculated that it played an important role in the evolutionary process. The researchers named this non-coding RNA "Testis-associated Highly-conserved Oncogenic long non-coding RNA" (THOR). THOR is highly expressed in cancer cells The author, Arul Chinnaiyan, a professor of pathology at the University of Michigan, led the team to screen thousands of potential lncRNAs in an attempt to map dark matter. In the end, they chose THOR for two reasons: first, THOR is highly conserved; second, THOR is highly expressed in testis tissue. Moreover, in some cancers including melanoma and lung cancer, the amount of THOR expression is abnormally high. When the gene is silenced, the tumor growth rate will slow down. For healthy cells, the lack of THOR is not affected. This means that THOR only affects cancer cells. Silencing THOR, inhibiting cell proliferation In further experiments, the team found that THOR interacts with insulin-like growth factor binding proteins (IGFBPs), which are thought to help maintain RNA stability. When THOR is silenced, IGFBPs activity is inhibited. This means that if THOR is disturbed, RNA stability is threatened, which in turn inhibits cell proliferation. When THOR is overexpressed, cell growth rate will increase. Researchers believe that THOR is expected to be a new target for anticancer drugs because they do not affect healthy cells. Original title: Surprise! Cell: Silence the "garbage" gene to stop tumor growth Reference materials: Silencing 'junk' gene could halt tumor growth Source: Bio-Exploration Dental Nitrile Gloves,Nitrile Gloves Large,Eu Medical Dental Gloves,Gloves Nitrile Disposable Gloves Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshihealths.com
Silent "garbage" genes can prevent tumor growth
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