Scientists find "new weapons" to completely eliminate cancer cells

Release date: 2017-06-23

The latest study, published in Cell, details how dead cells are replaced and how microbes kill cancer cells. Based on this finding, researchers have found new ways to reduce cancerous tumors.

The researchers said, "I believe that our research is critical to the development of cancer biology and anticancer drugs. For many years, we have been working on Pseudomonas aeruginosa, a deadly bacterium. Because this bacteria can secrete some of the toxin-producing toxin ExoT, the secreted toxin inhibits cell division and hinders wound healing, but it also kills cancer cells.

The researchers found out the mechanism when ExoT was unlocked and found that it was exactly the same as the cancer mechanism. Is this an accidental situation? In nearly 20 years of research, researchers have been trying to clarify the normal life cycle of cells and the process of death.

The researchers found that the lethality of the shiny P. aeruginosa is actually a process of "compensatory proliferation signal" (CPS).

In the process of observing CPS, the researchers found that dead cells release "microbubbles" containing CRKL proteins, and travel to neighboring cells to make them contact new cells that replace dead cells.

Apoptosis is part of the cell cycle. Humans die about one million cells per second. Apoptosis is not the only type of cell death. During this period, genes or ExoT toxins can prevent cells from competing for hyperplasia. The process by which P. aeruginosa uses damaged tissue also provides the possibility of disease.

Source: Noble

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