New aging markers found

On May 16, the National Geriatrics Center and Beijing Hospital held a news conference on new technologies. Professor Cai Jianping, Director of the Institute of Geriatrics, led his team to discover that the oxidative metabolites of RNA (ribonucleic acid) in human urine are 8-oxidized birds. The content of glycosides (8-oxoGsn) is a new senescence marker, providing a new scientific basis for more objective assessment of health and aging, biological age, and the study of aging-related diseases and the promotion of healthy aging. Related papers were published shortly in the journal "Ageing Frontiers in Neuroscience."

Cai Jianping said that one's age is divided by age and biological age. Among them, the chronological age is the age calculated by calendar after birth, and the biological age is more representative of the actual aging. It is often seen in daily life that the physiological function of different individuals at the same age is very different. Age is associated with an increased risk of death, and biological age is more closely related to health and aging.

Since the 1980s, a large number of researches on aging markers have begun in the world. However, most studies have focused on the pathological senescence caused by mutations in DNA (deoxyribonucleic acid). In the past 10 years, the Beijing hospital research team has conducted a beneficial exploration of the correlation between RNA oxidation and aging. The results of the study showed that the level of nucleic acid oxidation in systemic cells increases with age as mammals age.

Cai Jianping’s research team compared the level of nucleic acid oxidation in the visceral tissues of various mammalian tissues of mice, rats, and rhesus monkeys, and the level of nucleic acid oxidation metabolites in blood and urine. It was determined in 2012. The amount of oxidative metabolites of RNA in urine increased most significantly with age, suggesting that the oxidative metabolite of 8-oxidized guanosine in urine can be used as a new marker of aging in mammals and humans. This finding also suggests that RNA oxidation in human cells has important biological and clinical implications. In April of this year, the research team published an important research result of RNA oxidation-induced protein translation errors in the "NASA" (PNAS). It was observed that RNA oxidation can lead to an important marker of Alzheimer's disease - the number and type of amyloid Aβ. The apparent increase in this may be a new pathogenesis of Alzheimer's disease. (Reporter Gan Beibei)

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