Release date: 2015-08-04 Recently, a research report published in the international magazine Nature overturned a long-standing view of the scientific community about how energy is distributed in muscles for exercise. Scientists first discovered that muscle cells can charge through the mitochondrial network. Rapid conduction to distribute energy, this study may provide a new way to effectively clarify the molecular mechanism of mitochondrial energy plant for muscle contraction function, and also provide some clues for understanding the body of the body and energy utilization related diseases. Researcher Robert S. Balaban said that the rapid distribution of energy in muscle cells can alter scientists' perceptions of muscle function and function, as well as hope for studying human health and body disease. In the article, the researchers studied the function, mitochondrial structure and biochemical composition of mouse skeletal muscle cells. Using 3D electron microscopy and super-resolution optical imaging techniques, researchers found that most of the mitochondria can pass the transmission on similar municipal grids. A line forms a highly connected network. The mitochondrial "wires" are electrically conductive, and special probes have found that most mitochondria are directly connected or transmitted via a networked mode, which also means that mitochondria have electrical coupling. Sex, and can be quickly distributed on the mitochondrial membrane voltage, which is the raw energy produced by ATP. This study reveals how mitochondria are distributed throughout the muscle. The special arrangement of mitochondria allows the flow of potential energy to pass through the cells in the form of mitochondrial membrane voltage for ATP production, which in turn helps muscle contraction. Researcher Subramaniam pointed out that we originally developed these bioimaging techniques to study the mechanism of HIV-1 infection and the structural changes of melanoma cells, and we are very pleased that we have used these techniques to clarify the arrangement of mitochondria in muscles. Mechanism and energy supply strategy. The basic strategy of revealing the energy distribution of muscle cells may help to clarify the diagnosis and treatment direction of the disease. This study will help to develop new medical diagnostic techniques for diseases; in future research, scientists will use muscle biopsy or complex non-invasion. Sexual imaging techniques to explain how the loss of mitochondrial networks in muscle cells affects the development of many diseases. Source: Bio Valley
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Nature: High-resolution 3D imaging technology or energy network that clarifies mitochondria in muscle cells