Japanese medical research institutes develop 3D printed blood vessels and nerve technology

Japanese medical research institutes develop 3D printed blood vessels and nerve technology

At present, in the field of regenerative medicine , many research institutions in Japan are studying the use of 3D printing technology to produce complex tissues such as blood vessels. Saga University in Japan has printed a cell population of iPS cells (human induced pluripotent stem cells) into a tubular structure to form blood vessels. Kyoto University used 3D printing technology to make a nerve-like tubular tissue and transplant it into the experimental mouse to achieve nerve regeneration.

Japanese medical research institutes develop 3D printed blood vessels and nerve technology

The Japanese government predicts that by 2020, iPS cells will be used to treat diseases such as heart disease, and it is in the process of mastering the artificial three-dimensional tissue transplantation technology similar to the shape of human tissues.

iPS cells are not only used to treat difficult conditions in the eye, but may also be used to treat heart failure and spinal cord injury in the future. Tubular and pocket-like tissue structures often require the use of many cells when culturing long vessels and stereoscopic viscera for transplantation therapy. The research team believes that since the principle of 3D printing technology is to print a layered layer of resin material, if you use cells instead of resin, you can print a three-dimensional structure.

Saga University professor Morita Miki's research team cultured human iPS cells into a group of cells that can develop into blood vessels, and stratified the cells in a multi-row microneedle array of micro-pedestals, and finally printed a length of 2 cm. 5 mm tubular structure.

The tubular structure cells were removed from the fine needle and the culture medium was used internally. Differentiation into different kinds of cells after a few days will form a cell layer on the inner wall, eventually forming blood vessels. Vascular transplantation experiments will be carried out on pigs in the future.

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