Palatin Technologies Inc. (NYSE: PT-141) announced today that it has shown positive results in a Phase I clinical trial of pT-141 for the treatment of sexual dysfunction in normal premenopausal women.
The trial included 32 healthy female volunteers and evaluated their response to pT-141 and placebo in response to visual stimuli. Pt-141 was found to be safe and resulted in a significantly greater improvement in vaginal blood flow than placebo users (P< 0.05).
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Such antibiotics first affect the outer membrane of sensitive bacteria. Drug ring part of polypeptide amino and lipopolysaccharide in the outer membrane 2 valence cations combining site to produce electrostatic interaction, destroy the integrity of the outer membrane damage, fatty acid part of drugs to penetrate the outer membrane, thus increase the permeability of cell size, lead to intracytoplasmic phosphate, nucleosides and other small molecules to escape, straight die cause cell dysfunction. Gram-positive bacteria do not respond to such antibiotics because they have a thick cell wall that prevents drugs from entering the bacteria.
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Introduction to the main structure and usage of the tablet press>
The tablet press is mainly used for the tablet process research in the pharmaceutical industry. It is a kind of automatic continuous production equipment which presses the granular material into a circular shape with a diameter of not more than 13 mm and a graphic piece with characters, symbols and figures. The punches and dies of the tablet press are subjected to a large pressure during the tableting process, which is usually made of bearing steel and heat treated to increase its hardness. There are many types of punches, and the shape of the punch depends on the shape of the tablet. According to the shape of the die structure, it can be divided into a circular shape and a special shape; the shape of the cross section of the punch has a planar shape, a beveled shape, a shallow concave shape, a deep concave shape and a comprehensive shape. The flat, beveled punch is used to press flat cylindrical tablets, the shallow concave shape is used for pressing biconvex tablets, the deep concave shape is mainly used for pressing the coated tablets, and the integrated shape is mainly used for pressing. Shaped piece. In order to facilitate the identification and taking of drugs, the name, dose and vertical and horizontal lines of the drug can also be engraved on the end face of the die. For tablets of different doses, a suitable size should be selected.
In addition, the upper punch of the tablet press turret has a requirement on the structure of the tablet press. The requirement for the punch is increased because the upper punch needs to have a directional key, and the upper punch of the turntable is coordinated during the installation process. . The lower punch does not leave the middle die hole during the working process, and no other processing is required. Pressing the tablet punch with a profiled die is not free to rotate, but moves up and down along the upper and lower rails. When the turntable is driven, the punch and the guide rail are slidingly rubbed, so that the punch and the guide rail wear each other.
During the use of the tablet press, it is necessary to check the machine regularly, and perform 1-2 times a month. The inspection items are whether the worm gear, the worm, the bearing, the pressure wheel, the crankshaft, the upper and lower rail guides, etc. are flexible and wearable. , found that defects should be repaired in time.
When using it once or when it is stopped, remove the remaining powder and brush off the residual powder of each part of the machine. If the deactivation time is long, the die must be completely removed, and the machine should be wiped clean. The smooth surface of the machine is coated with anti-rust oil, which is covered with a cloth cover for convenient use.
The maintenance of the die should be placed in a special box, so that the die is completely invaded into the oil, and should be kept clean, not to cause rust and bruises. Zui can customize the special box to pack one box for each specification, which can avoid the use of Mistakes and help to grasp the damage.
The place of use should be cleaned frequently, especially for the manufacture of medicines and edible tablets, which are more suitable for the presence of sand and fly ash.
Electrical components should pay attention to working environment conditions, such as temperature, humidity, etc., in a good environment, will extend the life of the components. Pay attention to regular maintenance inspections and keep them in good working order. The cooling fan should periodically use compressed air to remove dust.
The maintenance of electrical components should be carried out by professional technicians. In particular, the inverter should be carefully handled. Under normal circumstances, it should be sent to a professional manufacturer for repair.
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