Improve the sensitivity of cancer detection to form active substances "micro droplets" Precision control cells Tianjin University high-frequency ultrasound research breakthrough November 21, 2018 Source: Health News A new technology can “attract†molecular aggregation and increase the concentration of cancer antigens by 100,000 times; a large sesame-sized resonator can reduce the liquid to “one billionth of a drop of waterâ€; a “sound scorpion†can Accurate manipulation of cells and micro-nanoparticles... Recently, under the guidance of Professor Hu Xiaotang, Professor Pang Wei and Professor Duan Xuexin, the MEMS team of Tianjin University has made major breakthroughs in research on high-frequency ultrasonic devices. Early detection of cancer is mainly directed at cancer antigens, which are macromolecules that cause immune responses, and the concentration of antigen molecules in various cancers such as prostate cancer is extremely low, which is difficult to detect by conventional methods. The team uses high-frequency ultrasonic micro-nano electromechanical resonators to generate three-dimensional acoustic flow fields and virtual micro-pocket effects in liquids, which can efficiently capture and aggregate biomolecules under physiological conditions, increasing the local concentration of molecules by 100,000 times. Highly sensitive detection at very low concentrations. The technology is biocompatible and easy to integrate with existing biosensors, providing new analytical tools and ideas for low-concentration detection in basic research, disease diagnosis, and drug development. The relevant research papers were published as cover articles in the journal "Academia Sinica Center Science" and "Physical Application Review". Biochips are predicted to be "the largest high-tech industry in the 21st century". The principle is to place biological samples on a very small piece of material and analyze the results by computer. The manufacture of biochips requires the formation of "microdroplets" of active substances such as proteins or DNA on very small areas. The "microdroplets" are extremely small in size, even comparable to human cells. Tianjin University developed high-frequency ultrasonic micro-droplet technology, using a high-frequency ultrasonic resonator that is not as large as sesame seeds to act on the surface of the liquid to form a stable "liquid peak." When the top of the peak contacts the planar substrate, a small amount of liquid is absorbed onto the surface of the substrate, forming a "microdroplet." The relevant research papers were published as cover articles in the journal "Laboratory" in the field of engineering technology. The sonar is an operating system based on sonic energy that can manipulate cells or tiny particles. Due to its advantages of low energy consumption and miniaturization, it has become a weapon in the fields of surgical medicine and bio-pharmaceuticals. The team combined high-frequency ultrasonic devices with microfluidic chips to master the new particle manipulation technology, the acoustic fluid. Compared with traditional sonar, the acoustic fluid has a smaller volume and more precise control. It can not only manipulate cells, but also sort, move, precisely control, and lyse cells, providing effective biomedical research, early diagnosis of diseases, etc. A tool that is accurate and biocompatible. The relevant research results were published as a cover article in the journal "Characterization of Particles and Particle Systems".
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Improve the sensitivity of cancer detection to form active substances "micro droplets" Precision control cells Tianjin University high-frequency ultrasound research breakthrough