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Product Synonym (Chinese Synonym): dextran sulfate; dextran sodium hydrogen sulfate, saccharide ester, sodium dextran sulfate, sodium dextran sulfate English synonym (English Synonym): Dextran Sulfate Sodium Salt, DSS; Dextran Sodium Sulfate
CAS number (CAS NO.): 9011-18-1
Purity ≥97%
Molecular Fomular: (C6H7Na3O14S3)n
Molecular Weight: 1352.4 g/mol
Appearance: light yellow or off-white powder
pH: 5~7.5
Solubility: Soluble in water, insoluble in ethanol and ether. The aqueous solution is a colorless or pale yellow clear liquid.
Soluble in water (100 mg/ml clear or slightly blurred yellow solution). The specific use concentration should be determined according to the type of modeling, with reference to relevant literature or by preliminary experiment.
Application field
1. Selective separation of lipoproteins: sodium dextran sulfate is often used to selectively isolate lipoproteins. Under the action of manganese ions, 0.05% sodium dextran sulfate (Mw 15,000) solution can make low density lipoprotein (LDL) (product number H2890.warbio) and very low density lipoprotein (VLDL) (item number H4890.warbio) Precipitation occurred. When the concentration of sodium dextran sulfate (Mw 15,000) was increased to 0.065%, high density lipoprotein (HDL) (Cat. No. H3740.warbio) also precipitated. Based on a similar principle, sodium dextran sulfate (Mw 500,000) was also used to detect high density lipoprotein in cholesterol.
2. Enteritis model reagent inducer: Ulcerative colitis (UC) is a chronic intestinal inflammatory disease whose etiology and pathogenesis are not well understood. Establish an appropriate animal model of colitis for studying the etiology and pathogenesis of UC. And new treatments are important. Sodium dextran sulfate (36,000~50,000) is used to prepare UC model of animals. The UC model induced by this method is the most similar to human UC, and is simple and easy to replicate. It is widely used in the screening of inflammatory bowel disease (IBD). New methods and the development of preclinical new drugs are also used to study the pathogenesis of IBD.
3. Increasing the nucleic acid hybridization rate: The solution contains 10% sodium dextran sulfate, and the reannealing rate of the DNA strand is increased by about 10 times. This phenomenon further expands the single-stranded or double-stranded probe and is fixed on the membrane. DNA/RNA hybridization rate. Moreover, the addition of 10% sodium dextran sulfate may increase the hybridization rate of the randomly cleaved double-stranded DNA probe to the immobilized nucleic acid by up to 100-fold. The wabo biomolecule bio-grade sodium dextran sulfate can be used for experiments in this area.
4. Other nucleic acid related applications: Sodium dextran sulfate has been shown to release nucleic acids from nucleic acid-histone complexes. Sodium dextran sulfate inhibits the binding of ribosomes, which is also a potent ribonuclease inhibitor and is used for the separation of ribosomes.
5. Miscellaneous applications: anticoagulant, contrast clear liquid, also used in photographic film manufacturing, clinically used to reduce blood fat and anti-coagulation, in vitro tests have shown anti-HIV effect.
â—†The advantages of dextran sulfate DSS-induced enteritis model animals Ulcerative colitis (UC) is a chronic intestinal inflammatory disease whose etiology and pathogenesis are not well understood. Establish an appropriate animal model of colitis for studying the etiology of UC. , pathogenesis and new treatment methods are of great significance. A variety of animal models were made to study it. Japanese scholars first applied dextran sulfate to prepare the mouse UC model in 1985. Since then, this method has been widely used to screen new methods and clinical treatments for inflammatory bowel disease (IBD). The development of pre-new drugs is also used to study the pathogenesis of IBD. It has the following advantages:
1. The pathological changes of the DSS-induced UC model are most similar to human UC;
2. This model can be applied to both the acute phase of UC and the study of chronic phase, so that the experiment can be carried out completely;
3. Easy to make, economical and easy to copy.
â—†Reference method:
method one:
The mice were given free drinking water containing 50 g/L dextran sulfate (sodium dextran sulfate) 5000 or 40,000 for 7 days, and the performance of acute enteritis such as weight loss, diarrhea and bloody stools appeared. Pathological sections were found by HE staining. The diseased colon gland was disordered, and mucosal and submucosal mononuclear cells and multinucleated cells were infiltrated. The expression of GSH in the intestinal tissue of the DSS group was significantly lower than that of the control group (2±0.6 vs 3.14±1.0, t = 3.95, P = 0.01<0.05). The IL-4 secreted by the diseased colon was significantly increased (38.7±4.7 vs 28.7±6.7, t=3.16, P= 0.009<0.01), and IFN-g was slightly decreased (P>0.05).
Source: "The role of GSH in DSS-induced experimental enteritis in mice"
Method Two:
Dissolve DSS with molecular weight of 50 00 or 40,000 in drinking water, prepare 3% DSS solution, let BALB/C mice drink for 7 days freely, establish a model of acute colitis in mice; 2 let BALB/C mice freely drink 3% DSS solution for 7 days, then drinking DSS distilled water for 14 days, established a mouse model of chronic colitis; the model was successfully established after drinking 3% DSS for 7 days, semi-lean stool, diarrhea, fecal occult blood (+) and gross blood in the stool Any symptom.
Source: Establishment and Evaluation of a Mouse Colitis Model Induced by Dextran Sulfate.
Studies have shown that different molecular weight DSS induce different lesion characteristics, such as feeding mice with 5000, 40 000 and 500 000 DSS, the typical lesions only appear in 5,000 groups and 40,000 groups, the main lesions in the 50,000 group In the cecum and upper colon, in addition, the severity of DSS colitis is not dependent on DSS intake, but is determined by the concentration of DSS. The difference in the amount of DSS consumed by mice does not affect the severity of colitis induced. Again, different species have different sensitivities to different molecular weight DSS.
Enteritis model animal modeling reagent - dextran sulfate Dextran Sulfate, Na (DSS)
Enteritis model animal modeling reagent - dextran sulfate Dextran Sulfate, Na (DSS)
Dextran sodium sulfate DSS, also known as dextran sulfate, is generally used in experimental animal models - induced colitis, sodium gluconate sulfate (sodium dextran sulfate), English Dextran Sulfate Sodium Salt, abbreviation DSS, is dextran A polyanionic derivative formed by the esterification of dextran and chlorolic acid. The sulfur content is about 17%, which corresponds to an average of 1.9 sulfuric acid groups per glucose residual sugar of the dextran molecule.
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