Apj Marks Tumor Neovascularization Provides Theoretical Basis for Targeted Neovascular Drug Development

Apj Marks Tumor Neovascularization Provides Theoretical Basis for Targeted Neovascular Drug Development

January 10, 2019 Source: Health News Author: Hu Derong

Zhou Bin, a research group of the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, recently used a model established by transgenic mice to track the expression of Apj, a G-protein coupled receptor, which is mainly enriched in tumor endothelial cells, and found that Apj can be specific. Sexually labeling most of the tumor neovascularization provides a theoretical basis for drug development targeting tumor neovascularization. Related research papers were published online in the journal Cell·Communication.

Tumor vascular targeted therapy is a new type of tumor treatment program that has emerged in recent years. The tumor-producing vascular system is used as a therapeutic target to inhibit tumor angiogenesis or block blood flow in tumor blood vessels. Relative to surgical therapy, radiotherapy, chemotherapy, etc., this method can inhibit the malignant proliferation of tumors without causing damage to surrounding normal tissues and organs, which is safe and reliable. However, currently used anti-tumor angiogenesis inhibitors, such as small molecule compounds targeting VEGF, tyrosine kinase inhibitors, MMP inhibitors, etc., still have certain therapeutic risks in patients with different diseases and different constitutions. Such as kidney failure, high blood pressure and blood clots.

Zhou Bin research team used Apj-CreER and Apj-DTRGFP-Luc transgenic mice to establish a subcutaneous tumor transplantation model, an orthotopic tumor transplantation model, a gene defect in situ tumor model, and a compound-induced tumor model, and were irrigated at specific time points. Gastropoxime, using the genetic lineage tracing technique to track the expression of Apj, found that Apj can specifically label most tumor neovascularizations without labeling blood vessels in other healthy adult organs. In-depth studies have shown that specific inhibition or clearance of Apj-positive cells after the establishment of a subcutaneous tumor transplantation model can significantly inhibit angiogenesis and tumor proliferation.

Transforaminal Endoscopy Instruments

We're professional Transforaminal Endoscopy Instruments manufacturers and suppliers in China, specialized in providing high quality medical instruments with reasonable price. We warmly welcome you to buy or wholesale bulk Transforaminal Endoscopy Instruments for sale here and get quotation from our factory.

Transforaminal Endoscopic,Transforaminal Locating Ruler,Transforaminal Biting Forceps,Transforaminal Endoscopy Instruments

Tonglu WANHE Medical Instrument Co., Ltd , https://www.vanhurhealth.com